When a submission is made to your organization, it will appear in your Submissions List with a New status. From the submitter's view, a new submission will show as Received in their submission list. As soon as the first action is taken on a submission - such as assigning it to a reviewer or leaving a note or a review - the submission will automatically change to an In-Progress status. (Note: if submissions are set to be auto-assigned, this auto-assignment will not trigger a change from New to In-Progress. Only manually assigned submissions will cause that status change.)
Once a submission is In-Progress, all subsequent status changes need to be made by site administrators (Level 4 or Level 5). Status changes can be made in bulk from the Submissions List page, or individually from the Submission Details page. Most often, administrators will send a response template or email message when changing a submission to a terminal status. However it is also possible to change submission's status without notifying the submitter. The option to change a submission status without emailing the submitter will appear in the status-change dialog box in the Response Template dropdown option. The only time this option will not be available is when you are changing a status to Editable, in which case it is mandatory to notify the submitter.
Additionally, if you have a blind form set up, any time a submission from that form is changed to a terminal status (Accepted, Declined, Completed, Withdrawn), the blind setting will be removed from that submission, and assigned reviewers will be able to see all of the previously blinded information.